Journal
JOURNAL OF CHROMATOGRAPHY A
Volume 1218, Issue 41, Pages 7254-7263Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.chroma.2011.08.063
Keywords
Ionic liquid-based homogeneous liquid-liquid microextraction (IL-based HLLME); Fluroquinolones; Sulfonamides; Milk samples
Funding
- Quality Inspection Community Service Foundation, PR China [200810474]
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Ionic liquid-based homogeneous liquid-liquid microextraction (IL-based HLLME) high-performance liquid chromatography was developed and applied to the extraction, separation and determination of some antibiotics in milk. The proteins and lipids were removed by adding salt and adjusting the pH value. The homogeneous extraction was applied to the improvement of recoveries for IL phase and analytes. The experimental parameters of the IL-based HLLME, including salt concentration in sample solution, pH value of sample solution, volume of [C6MIM][BF4], amount of ion-pairing agent (NH4PF6), and extraction time, were evaluated. The limits of detection for enoxacin, pefloxacin, norfloxacin, enrofloxacin, sulfamethoxazole and sulfadimethoxine were 15.8, 7.07, 5.13, 4.00, 7.79 and 8.33 mu g L-1, respectively. When the proposed method was applied to the analysis of milk samples the recoveries of the analytes ranged from 92.5 to 118.6% and relative standard deviations were lower than 7.00%. (C) 2011 Elsevier B.V. All rights reserved.
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