Journal
JOURNAL OF CHROMATOGRAPHY A
Volume 1218, Issue 38, Pages 6727-6731Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.chroma.2011.07.090
Keywords
Enantioseparation; Terbutaline; Salbutamol; Chirobiotic V; Polar ionic mode
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In this study, a method for enantioseparation of terbutaline and salbutamol was established using Chirobiotic V column as a stationary phase. Polar ionic mode applying mobile phase containing ammonium nitrate in 100% ethanol, pH 5.1 was found to give the best separation. The salt concentration in the mobile phase and pH value were found to be the most important chromatographic factors affecting separation. Separation of enantiomers of these two basic analytes was complete in less than 10 min without applying ammonium trifluoroacetate (ATFA) or triethylamine (TEA) salts. (C) 2011 Elsevier B.V. All rights reserved.
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