Journal
JOURNAL OF CHROMATOGRAPHY A
Volume 1218, Issue 36, Pages 6144-6147Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.chroma.2010.12.090
Keywords
Process scale; Toroidal coil chromatography; TCC
Funding
- Biotechnology and Biological Sciences Research Council [BB/C506364/1] Funding Source: researchfish
- Biotechnology and Biological Sciences Research Council [BB/FOF/206, BB/C506364/1] Funding Source: Medline
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Selected test results have been taken from various publications and resolution and stage efficiency measured using an established model. All experiments used the same sample and, where possible, the same sample loading. The results show that stage mixing efficiencies have increased from 1.1% in 1998 to greater than 25% in the latest scaled-up version of a Toroidal coil chromatography (TCC) instrument working at 240 g. (C) 2011 Elsevier B.V. All rights reserved.
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