Journal
JOURNAL OF CHROMATOGRAPHY A
Volume 1218, Issue 38, Pages 6712-6719Publisher
ELSEVIER
DOI: 10.1016/j.chroma.2011.07.071
Keywords
Liquid chromatography-time-of-flight-mass spectrometry; Multiresidue method; Solid phase extraction; Emerging contaminants
Funding
- Helsinki University Centre for Environment (HENVI), Ramboll Finland Oy
- Onni and Hilja Tuovinen Foundation
- Vesihuoltolaitosten kehittamisrahasto
- Lake Vesijarvi Foundation
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A multiresidue method for screening of emerging contaminants in aquatic environments was developed. The method was based on sample pretreatment with solid phase extraction (SPE) and analysis with an ultra performance liquid chromatograph-time-of-flight mass spectrometer (UPLC-TOF-MS). The method was optimized and tested with standard solutions of model compounds containing 84 pesticides and pharmaceuticals. Four different SPE sorbents were evaluated to gain maximum recovery for the analytes. For the final procedure a combination of two different sorbents was chosen. In spite of high matrix suppression, the method quantification limits (MQLs) were acceptable. Therefore, the method can be used for screening known target compounds. The applicability of the method for posttarget and nontarget screening will be reported later. To preliminarily assess the quantitative performance of the method, some compounds in wastewater effluent were quantified using the standard addition method. Three pesticides and eight pharmaceuticals were found in concentrations up to similar to 2200 ng/L (C) 2011 Elsevier B.V. All rights reserved.
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