Journal
JOURNAL OF CHROMATOGRAPHY A
Volume 1218, Issue 23, Pages 3648-3653Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.chroma.2011.04.016
Keywords
(S)-Naproxen; Benzotriazole; Penicillamine; Cysteine; Homocysteine; High performance liquid chromatography; Enantioseparation
Funding
- Council of Scientific and Industrial Research (CSIR), New Delhi
- Council of Scientific and Industrial Research (CSIR), New Delhi, India [01(2334)/09 EMR-II]
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(S)-Naproxen-benzotriazole was synthesized by the reaction of (S)-naproxen with 1H-benzotriazole using coupling reagent dicyclohexyl carbodiimide and 4-dimethylamino pyridine (DCC/DMAP). It was used as chiral derivatizing reagent for microwave irradiated synthesis of diastereomers of penicillamine, cysteine and homocysteine. The diastereomers were separated by reversed phase high performance liquid chromatography using gradient elution of triethylammonium phosphate (pH 3.5)-acetonitrile (30-65% within 30 min). The method was validated for accuracy, precision, and limit of detection. (C) 2011 Elsevier B.V. All rights reserved.
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