Journal
JOURNAL OF CHROMATOGRAPHY A
Volume 1217, Issue 25, Pages 4071-4078Publisher
ELSEVIER
DOI: 10.1016/j.chroma.2009.08.061
Keywords
Matrix effects; Ion suppression; Plasma; Urine; Sample preparation; SPE; MS
Ask authors/readers for more resources
An exhaustive classification of matrix effects occurring when a sample preparation is performed prior to liquid-chromatography coupled to mass spectrometry (LC-MS) analyses was proposed. A total of eight different situations were identified allowing the recognition of the matrix effect typology via the calculation of four recovery values. A set of 198 compounds was used to evaluate matrix effects after solid phase extraction (SPE) from plasma or urine samples prior to LC-ESI-MS analysis. Matrix effect identification was achieved for all compounds and classified through an organization chart. Only 17% of the tested compounds did not present significant matrix effects. (C) 2009 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available