Journal
JOURNAL OF CHROMATOGRAPHY A
Volume 1217, Issue 25, Pages 3966-3977Publisher
ELSEVIER
DOI: 10.1016/j.chroma.2010.02.058
Keywords
Off-line coupling; Microcolumn separation; Mass spectrometry; Spotter; Deposition interface
Funding
- Czech Science Foundation [203/09/1025, P206/10/J012]
- Ministry of Education, Youth and Sports of the Czech Republic [MSM0021622415]
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The presented review provides comprehensive and detailed characteristics on microcolumn separation techniques off-line coupled to mass spectrometry. Major attention is paid to the classification of junctions between the separation column and the deposition needle and to the process by which the liquid is transferred onto the target. Both contact and non-contact deposition techniques are covered. In order to emphasize the significance of the topic of off-line separations, current commercially available devices have been compared in terms of their potential utilization in analytical chemistry with a summarization of applications used over the past few years. (C) 2010 Elsevier B.V. All rights reserved.
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