Journal
JOURNAL OF CHROMATOGRAPHY A
Volume 1216, Issue 16, Pages 3594-3599Publisher
ELSEVIER
DOI: 10.1016/j.chroma.2009.02.057
Keywords
Ionic liquid; 1-Octyl-3-propylimidazolium chloride; Stationary phase; Supercritical fluid chromatography
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We packed an ionic liquid (IL)-functionalized stationary phase - based on 1-octyl-3-propylimidazolium chloride covalently bounded to silica gel - into a 3.2 mm x 250 mm column for the simultaneous separation of acidic, basic, and neutral compounds using carbon dioxide subcritical/supercritical fluid chromatography (SFC), and examined the effects of the pressure, temperature, co-solvents, and additives on the retention behavior of the analytes. The model compounds tested for SFC separation are acetaminophen, metoprolol, fenoprofen, ibuprofen, naphthalene, and testosterone. The data indicate that hydrogen-bonding and hydrophobic interactions between the analytes and the IL-modified stationary phase seem to involve in the separation process. Simultaneous separation of acidic, basic, and neutral compounds via SFC was successful at a co-solvent content of 20% MeOH, a pressure of 110bar, and a column temperature of 35 C. The relative standard deviations of the retention times and peak areas at 50 ppm were all less than 4 and 8% (n = 6), respectively. (C) 2009 Elsevier B.V. All rights reserved.
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