Journal
JOURNAL OF CHROMATOGRAPHY A
Volume 1216, Issue 25, Pages 4957-4962Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.chroma.2009.04.071
Keywords
Restricted access media; Molecularly imprinted polymer; Sample preparation; Liquid chromatography-tandem mass spectrometry; Environmental analysis; Cyclobarbital; Phenobarbital; Amobarbital; Phenytoin
Funding
- Ministry of Environment
- Ministry of Education, Culture, Sports, Science and Technology, Japan [19390013]
- Grants-in-Aid for Scientific Research [19390013] Funding Source: KAKEN
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A restricted access media-molecularly imprinted polymer (RAM-MIP) for cyclobarbital has been developed for selective extraction of antiepileptics in river water samples. The RAM-MIP was prepared using 4-vinylpyridine and ethylene glycol dimethacrylate as a functional monomer and cross-linker, respectively, by a multi-step swelling and polymerization method followed by a surface modification technique. The RAM-MIP for cyclobarbital showed molecular recognition abilities for phenobarbital, amobarbital and phenytoin as well as cyclobarbital. Thus, selective analysis of antiepileptics in river water samples was attained with RAM-MIP extraction followed by column-switching liquid chromatography-tandem mass spectrometry. The concentrations of phenobarbital and phenytoin in river water samples were about 15 and 4 ng/L, respectively, while that of amobarbital was below the limit of quantitation. (C) 2009 Elsevier B.V. All rights reserved.
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