Journal
JOURNAL OF CHROMATOGRAPHY A
Volume 1216, Issue 46, Pages 8165-8172Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.chroma.2009.07.036
Keywords
Benzimidazoles; Levamisole; Triclabendazole; Residues; Milk; LC-MS; Marker residue
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The screening method for the determination of residues of 19 benzimidazoles (parent drugs and their metabolites) and levamisole in bovine milk has been developed and validated. Milk samples were extracted with ethyl acetate, sample extracts were cleaned up by liquid-liquid partitioning with hexane and acidic ethanol. Liquid chromatography-single-quadrupole mass spectrometry was used for the separation and determination of analytes. The method was validated in bovine milk, according to the CD 2002/657/EC criteria. An alternative approach to the validation of the method was applied (sum MRL substances). The method was successfully verified in CRL proficiency test. (C) 2009 Elsevier B.V. All rights reserved.
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