Journal
JOURNAL OF CHROMATOGRAPHY A
Volume 1216, Issue 37, Pages 6459-6465Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.chroma.2009.07.040
Keywords
Dispersive liquid-liquid microextraction; Ionic liquid; Urine; Liquid chromatography
Funding
- Spanish DGICyT [CTQ200760426]
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Dispersive liquid-liquid microextraction (DLLME) has been proved to be a powerful tool for the rapid sample treatment of liquid samples providing at the same time high enrichment factors and extraction recoveries. A new, simple and easy to handle one step in-syringe set-LIP for DLLME is presented and critically discussed in this paper. The novel approach avoids the centrifugation step, typically off-line and time consuming, opening-up a new horizon on DLLME automation. The suitability of the proposal is evaluated by means of the determination of non-steroidal anti-inflammatory drugs in urine by liquid chromatography/ultraviolet detection. In the presented approach an ionic liquid is used as extractant. The target drugs can be determined in urine within the concentration range 0.02-10 mu g mL(-1), allowing their determination at therapeutic and toxic levels. Limits of detection were in the range from 8.3 ng mL(-1) (indomethacin) to 32 ng mL(-1) (ketoprofen). The repeatability of the proposed method expressed as RSD (n = 5) varied between 2.5% (for ketoprofen) and 8.6% (for indomethacin). (C) 2009 Elsevier B.V. All rights reserved.
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