Journal
JOURNAL OF CHROMATOGRAPHY A
Volume 1216, Issue 23, Pages 4693-4702Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.chroma.2009.04.025
Keywords
Parabens; Triclosan; Wateranalysis; Solid-phase microextraction; Microextraction; Headspace analysis; Derivatization; Experimental design
Funding
- FEDER [CTQ2006-03334]
- Xunta de Galicia [PGIDT06PXI3237039PR]
- Ministerio de Ciencia y Tecnologia
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An in situ derivatization sohd-phase microextraction method has been developed for the determination of parabens, triclosan and related chlorophenols in water. Acetylated derivatives are selectively determined using gas chromatography with tandem mass spectrometry. Parameters affecting both derivatization and SPME procedures, such as fiber coating, extraction mode, temperature, volume of derivatizating reagent and ionic strength, are studied and optimized through a multifactorial experimental design. The Quantitative recoveries (>= 82%) and satisfactory precision (RSD <= 12%) are obtained. Limits of detection at the low picogram per millilitre level are achieved for all target Compounds. Linearity is studied in a wide range of concentrations and an analysis of variance with a lack-of-fit test is run to validate the calibration data. Extraction time profiles are also obtained. Finally, the applicability of the proposed method is demonstrated for several real samples including river water, wastewaters and swimming pool water. Since no matrix effects are observed, quantification can readily be carried Out by external calibration with ultrapure water standards. (C) 2009 Elsevier B.V. All rights reserved.
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