Journal
JOURNAL OF CHROMATOGRAPHY A
Volume 1216, Issue 16, Pages 3488-3491Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.chroma.2008.10.029
Keywords
Capillary electrophoresis; Chiral separation; Dodecoxycarbonylvaline; Microemulsion electrokinetic chromatography; Chiral surfactant; Impurity analysis
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Numerous combinations of one-,two-,and three-chiral-component microemulsions have been previously prepared in our group, using N-dodecoxycarbonylvaline (DDCV), 2-hexanol, and ethyl acetate, dibutyl tartrate, or diethyl tartrate. A few results of the various formulations investigated suggested the possible presence of minor impurities in one or more components of the microemulsion. In this study, the purity of the current lots of R- and S-surfactant were measured, as was the subsequent effect of minor impurities on the relevant chromatographic figures of merit (CFOMs) that describe a chiral separation, i.e., efficiency, enantioselectivity, retention, migration window (elution range), and resolution. Two related methods are proposed for correcting enantioselectivities measured in the presence of chiral impurities in the chiral microemulsion. (C) 2008 Elsevier B.V. All rights reserved.
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