Journal
JOURNAL OF CHROMATOGRAPHY A
Volume 1216, Issue 32, Pages 6020-6023Publisher
ELSEVIER
DOI: 10.1016/j.chroma.2009.06.036
Keywords
GC-MS; Headspace; Ionic liquid; Residual solvent
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1-n-Butyl-3-methylimidazolium dimethyl phosphate (BMIM DMP) was identified as the most suitable ionic liquid as solvent for the headspace gas chromatographic analysis of solvents with very low vapor pressure such as dimethylsulfoxide, N-methylpyrrolidone, sulfolane, tetralin, and ethylene glycol in a realistic matrix of commonly used excipients (carboxymethylcellulose, magnesium stearate, guar flour, and corn starch) in pharmaceutical products. Limits of quantification and limits of detection were in the low microgram per gram range. The detection of traces of sulfolane in a real sample of tablets containing the drug cefpodoxim proxetil demonstrated the applicability of the method. (C) 2009 Elsevier B.V. All rights reserved.
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