Journal
JOURNAL OF CHROMATOGRAPHY A
Volume 1216, Issue 50, Pages 8787-8792Publisher
ELSEVIER
DOI: 10.1016/j.chroma.2009.03.040
Keywords
Process scale; Intermittent counter-current extraction; Counter-current chromatography; CCC; GUESS; ICcE
Funding
- BBSRC [BB/D524583/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/D524583/1] Funding Source: researchfish
- Biotechnology and Biological Sciences Research Council [BB/D524583/1, BBD524583/1, 192/SBRI9675] Funding Source: Medline
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Predictable scale-up from test tube derived distribution ratios and analytical-scale sample loading optimisation is demonstrated using a model sample system of benzyl alcohol and p-cresol in a heptane:ethyl acetate: methanol:water phase system with the new 18 L Maxi counter-current chromatography centrifuge. The versatility of having a liquid stationary phase with its high loading capacity and flexible operating modes is demonstrated at two different scales by separating and concentrating target compounds using a mixture of caffeine, vanillin, naringenin and carvone using a quasi-continuous technique called intermittent counter-current extraction. (C) 2009 Elsevier B.V. All rights reserved.
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