Journal
JOURNAL OF CHROMATOGRAPHY A
Volume 1191, Issue 1-2, Pages 231-252Publisher
ELSEVIER
DOI: 10.1016/j.chroma.2008.02.029
Keywords
monolithic silica columns; reversed-phase; polymerization; chemical modification; HPLC; HILIC; ion-exchange; chiral; stationary phase
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Preparation methods of monolithic silica columns for HPLC including the surface modification were reviewed. Chemical modification methods recently reported to obtain stationary phases for reversed-phase (RP), chiral, ion-exchange, and hydrophilic interaction chromatography (HILIC) separations were discussed. Recent results related to preparation methods of monolithic silica were also covered. The characteristics and properties of silica monoliths and some applications of monolithic silica columns for different analytical and bioanalytical fields will be commented. (c) 2008 Elsevier B.V. All rights reserved.
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