Journal
JOURNAL OF CHROMATOGRAPHY A
Volume 1208, Issue 1-2, Pages 175-181Publisher
ELSEVIER
DOI: 10.1016/j.chroma.2008.08.090
Keywords
Amino acid ionic liquid; Task-specific ionic liquid; Quantification; LC-MS; Ion pair-reversed phase chromatography; Molar ratio; pl; Polarity
Funding
- National Basic Research Program of China (973 Program) [2006CB504701]
- National Natural Science Foundation of China [20575019, 20335020]
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Amino acid ionic liquids (AAILs) containing imidazolium cations and amino acid (AA) anions, were synthesized and applied as task-specific ionic liquids. A sensitive and fast liquid chromatography-mass spectrometry (LC-MS) method was established for the quantitative analysis of 20 AAILs. Using ion pairing-reversed phase liquid chromatography technique, heptafluorobutyric acid was used as ion-pairing reagent to increase the retention of AAILs. Based on the zwitterionity of amino acid, this method was proposed to determine both the cation and the anion of AAILs simultaneously. The limit of detection of this method is down to 1-15 ng/mL and the analysis time is less than 15 min. According to the analytical data of seven selected AAILs, we found that the content of amino acid anion is always lower than that of butyl methyl imidazolium cation in AAILs. Moreover, the molar ratio of imidazolium cation to amino acid anion is dependent on the chemical property of the amino acid. These results supplied useful information on the interaction of imidazolium cation with acidic, basic, neutral and non-polar amino acids in AAILs. (C) 2008 Elsevier B.V. All rights reserved.
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