Journal
JOURNAL OF CHROMATOGRAPHY A
Volume 1189, Issue 1-2, Pages 285-291Publisher
ELSEVIER
DOI: 10.1016/j.chroma.2007.09.054
Keywords
column liquid chromatography; beta-3-homo-amino acids; (+)-(18-crown-6)-2,3,11,12-tetracarboxylic acid-based chiral stationary phase
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High-performance liquid chromatographic methods were developed for the separation of the enantiomers of thirteen unusual beta-3-homo-amino acids and three of its ethyl esters on a chiral stationary phase containing (+)-(18-crown-6)-2,3,11,12-tetracarboxylic acid as chiral selector. The effects of the mobile phase composition and the acidic modifiers on the separation were investigated. The structures of the substiments in beta-position substantially influenced the retention and enantioseparation. The influence of ionic strength. on the enantioseparation was established experimentally. The elution sequence was determined in all cases. (c) 2007 Elsevier B.V. All rights reserved.
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