Journal
JOURNAL OF CHROMATOGRAPHY A
Volume 1184, Issue 1-2, Pages 144-158Publisher
ELSEVIER
DOI: 10.1016/j.chroma.2007.10.098
Keywords
capillary electrophoresis; neuroscience; neurotransmitters; cell-to-cell signaling; neuronal release; single cell analysis; microdialysis
Funding
- NIDA NIH HHS [P30 DA 018310, P30 DA018310] Funding Source: Medline
- NINDS NIH HHS [R01 NS031609] Funding Source: Medline
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Capillary electrophoresis (CE) is a small-volume separation approach amenable to the analysis of complex samples for their small molecule, peptide and protein content. A number of the features of CE make it a method of choice for addressing questions related to neurochemistry. The figures of merit inherent to CE that make it well suited for studying cell-to-cell and intracellular signaling include small sample volumes, high separation efficiency, the ability for online analyte concentration, and compatibility with sensitive and high-information content detection methods. A variety of instrumental aspects are detailed, including detection methods and sampling techniques that are particularly useful for the analysis of signaling molecules. Studies that have used these techniques to increase our understanding of neurobiology are emphasized throughout. One notable application is single neuron chemical analysis, a research area that has been greatly advanced by CE. (c) 2007 Elsevier B.V. All rights reserved.
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