Journal
JOURNAL OF CHROMATOGRAPHY A
Volume 1203, Issue 2, Pages 185-192Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.chroma.2008.07.046
Keywords
beta-cyclodextrin derivatives; chiral stationary phases; supercritical fluid chromatography; high-performance liquid chromatography; enantioseparation
Funding
- Singapore Ministry of Education Academic Research [ARC 9/06]
- NTU
Ask authors/readers for more resources
Four cationic beta-cycloclextrin derivatives, namely mono-6-(3-methylimidazolium)-6-deoxy-perphenyl-carbamoyl-beta-cyclodextrin chloride (MPCCD), mono-6-(3-methylimidazolium)-6-deoxyper(3,5-dimethylphenylcarbamoyl)-beta-cyclodextrin chloride (MDPCCD), mono-6-(3-octylimidazolium)-6-deoxyperphenylcarbamoyl-beta-cyclodextrin chloride (OPCCD) and mono-6-(3-octylimidazolium)-6-deoxyper(3,5-dimethylphenylcarbamoyl)-beta-cyclodextrin chloride (ODPCCD), have been synthesized and physically coated onto porous spherical silica gel to obtain novel chiral stationary phases (CSPs). The performances of these CSPs are studied on high-performance liquid chromatography (HPLC) and supercritical fluid chromatography (SFC) using 18 racemic aryl alcohols as test analytes. Among these four CSPS, OPCCD shows the best separation results for all analytes on both HPLC and SFC analyses. Chromatographic studies reveal that the CSPs consisting of an n-octyl group on the imidazolium moiety and phenylcarbarnoyl groups On the cyclodextrin ring provide enhancement of analyte-chiral Substrate interactions over CSPs bearing the methyl group on the imidazolium moiety and 3,5-dimethylphenylcarbamoyl groups on the cyclodextrin ring. (C) 2008 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available