Journal
JOURNAL OF CHROMATOGRAPHY A
Volume 1195, Issue 1-2, Pages 146-149Publisher
ELSEVIER
DOI: 10.1016/j.chroma.2008.05.020
Keywords
Hansen solubility parameters; inverse gas chromatography; interaction coefficient; pharmaceutical excipients
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The Hansen solubility parameter (HSP) seems to be a useful tool for the thermodynamic characterization of different materials. Unfortunately, estimation of the HSP values can cause some problems. In this work different procedures by using inverse gas chromatography have been presented for calculation of pharmaceutical excipients' solubility parameter. The new procedure proposed, based on the Lindvig et al. methodology, where experimental data of Flory-Huggins interaction parameter are used, can be a reasonable alternative for the estimation of HSP values. The advantage of this method is that the values of Flory-Huggins interaction parameter X for all test solutes are used for further calculation, thus diverse interactions between test solute and material are taken into consideration. (C) 2008 Elsevier B.V. All rights reserved.
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