Journal
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
Volume 56, Issue 6, Pages 632-639Publisher
WILEY-BLACKWELL
DOI: 10.1111/jcpp.12337
Keywords
ADHD; gender difference; neuropsychology; cognitive development; mediation
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Funding
- National Institute of Mental Health [F31MH099749]
- National Institute for Child Health and Human Development [HD27802]
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BackgroundMales show higher rates of attention deficit hyperactivity disorder (ADHD) than do females. Potential explanations include genuine etiological differences or artifact. Methods2,332 twin and sibling youth participated in behavioral and cognitive testing. Partially competing models of symptom severity distribution differences, the mean difference, and variance difference models, were tested within a randomly selected subsample. The Delta method was used to test for mediation of sex differences in ADHD symptom severity by processing speed, inhibition and working memory. ResultsThe combined mean difference and variance difference models fully explained the sex difference in ADHD symptom severity. Cognitive endophenotypes mediated 14% of the sex difference effect. ConclusionsThe sex difference in ADHD symptom severity is valid and may be due to differing genetic and cognitive liabilities between the sexes.
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