Journal
JOURNAL OF CHILD NEUROLOGY
Volume 29, Issue 2, Pages 182-186Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/0883073813488829
Keywords
cytokine; febrile seizures; severe acute encephalitis; interleukin-6; inflammation
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Funding
- Chang Gung Memorial Hospital, Taiwan [CMRPG 391261]
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We investigated the plasma cytokine profiles of children with febrile seizures or severe acute encephalitis using multiplex cytometry to evaluate the role of cytokines in these diseases. Interleukin-6, -10, -12p70, -17A, -2, -4, -5, -9, -13, -22, and -1, interferon-, and tumor necrosis factor- were measured in the plasma from children with febrile seizures (n = 9) or severe acute encephalitis (n = 21). In multivariate analysis, interleukin-6 was significantly increased in the plasma of the febrile seizure patients compared to those with severe acute encephalitis, suggesting that interleukin-6 is activated during the acute stage of a febrile seizure. A lower plasma interleukin-6 concentration was significantly associated with severe acute encephalitis. The cytokine network may be deregulated in severe acute encephalitis via the persistence of an uncontrolled inflammatory state in the brain.
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