Journal
JOURNAL OF CHILD NEUROLOGY
Volume 25, Issue 9, Pages 1130-1144Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/0883073810371509
Keywords
Duchenne muscular dystrophy; clinical outcome measures; health-related quality of life; clinical trials; Pediatric Outcomes Data Collection Instrument (PODCI); Pediatric Quality of Life Inventory (PedsQL)
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Funding
- NINDS NIH HHS [R13 NS040925, 5R13NS040925-09] Funding Source: Medline
- PHS HHS [H133B090001] Funding Source: Medline
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In Duchenne muscular dystrophy, data directly linking changes in clinical outcome measures to patient-perceived well-being are lacking. This study evaluated the relationship between clinical outcome measures used in clinical trials of ambulatory Duchenne muscular dystrophy (Vignos functional grade, quantitative knee extension strength, timed functional performance measures, and gait velocity) and 2 health-related quality of life measures-the Pediatric Outcomes Data Collection Instrument and Pediatric Quality of Life Inventory-in 52 ambulatory Duchenne muscular dystrophy subjects and 36 controls. Those with the disease showed significant decrements in parent proxy-reported health-related quality of life measures versus controls across all domains. The Pediatric Outcomes Data Collection Instrument transfers/basic mobility and sports/physical function and the Pediatric Quality of Life Inventory physical functioning domains had significant associations with age (and hence disease progression) and traditional clinical outcome measures employed in clinical trials of ambulatory boys with Duchenne muscular dystrophy. Selected domains of the Pediatric Outcomes Data Collection Instrument and generic Pediatric Quality of Life Inventory are potential patient-reported outcome measures for clinical trials in ambulatory individuals with the disease.
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