Journal
JOURNAL OF CHILD NEUROLOGY
Volume 25, Issue 4, Pages 441-447Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/0883073809348355
Keywords
Lennox-Gastaut syndrome; infantile spasms; mortality; epilepsy
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Funding
- Washington University in St Louis [03-IPA05200]
- National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention (CDC) [03-IPA05200]
- Alexander C. Graebe Memorial Fund
- Jason Sears and Edy Sumner Memorial Fund
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The magnitude and causes of death among a cohort of children with epilepsy were determined. A follow-up study with a population-based cohort of 10-year-old children in the metropolitan Atlanta area with epilepsy was conducted. The National Death Index and linkage to State of Georgia death certificates were used to identify deaths. The authors estimated the expected numbers of deaths by applying mortality rates adjusted by age, race, and sex for the entire state of Georgia to the population for the follow-up period. Among the 688 children who were in the final epilepsy cohort, 64 deaths occurred; 20.6 deaths were expected (mortality ratio adjusted for age, race, and sex = 3.11). The mortality ratios for children with Lennox-Gastaut syndrome and infantile spasms were 13.92 and 11.91, respectively. Children and adolescents with epilepsy, especially those with Lennox-Gastaut syndrome or infantile spasms, have an increased risk of death.
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