Journal
JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY
Volume 19, Issue 6, Pages 623-633Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/cap.2009.0035
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Funding
- Boehringer Ingelheim
- Bristol Myers Squibb
- National Institute of Mental Health
- National Institute of Neurological Disorders and Stroke
- Tourette Syndrome Association
- American Academy of Child and Adolescent Psychiatry
- Boards of Jazz Pharmaceuticals and Novartis
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Objective: The aim of this study was to conduct a prospective safety and tolerability study of aripiprazole for the treatment of tics in children and adolescents with Tourette's disorder (TD). Method: Eleven subjects (10 males) withTD(age 9-19 years, mean 13.36, standard deviation [SD] 3.33) who did not respond or were unable to tolerate previous tic medication were treated with aripiprazole in an open-label, flexible-dosing study over 10 weeks. Tic severity was rated using the Yale Global Tic Severity Scale (YGTSS) and the Clinical Global Impressions Scale for tics (CGI-Tics) at baseline and at follow-up. Results: The mean (+/- SD) daily dose for aripiprazole was 4.5 +/- 3.0 mg. Mean (+/- SD) YGTSS Global Severity scores reduced from 61.82 +/- 13.49 at baseline to 33.73 +/- 15.18 at end point; mean YGTSS total tic scores reduced from 28.18 +/- 7.74 at baseline to 16.73 +/- 7.54 at end point. Mean (+/- SD) CGI-Tic severity scores reduced from 4.45 +/- 0.52 (moderate-marked) at baseline to 3.18 +/- 0.60 (mild) at end point. On the CGI- Tic improvement scale, 10 (91%) subjects achieved 1 (very much improved'') or 2 (much improved'') at end point. Most common adverse effects included appetite increase and weight gain in 5 subjects, mild extrapyramidal effects in 7 subjects, and headaches and tiredness/fatigue in 7 subjects; 1 subject experienced akathisia and muscle cramps. Conclusion: Aripiprazole appears to be a safe and tolerable treatment in children and adolescents with TD that appears to reduce tics; it should be further investigated as a treatment option in controlled trials.
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