Journal
NEUROPHARMACOLOGY
Volume 94, Issue -, Pages 42-48Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuropharm.2014.12.010
Keywords
Proton; Acidosis; ASIC; Neuronal injury; Synaptic plasticity
Categories
Funding
- NIH [R01NS066027, U54NS083932]
- NIMHD [S21MD000101]
- American Heart Association [13SDG13970009]
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Extracellular brain pH fluctuates in both physiological and disease conditions. The main postsynaptic proton receptor is the acid-sensing ion channels (ASICs). During the past decade, much progress has been made on protons, ASICs, and neurological disease. This review summarizes the recent progress on synaptic role of protons and our current understanding of how ASICs contribute to various types of neuronal injury in the brain. (C) 2015 Elsevier Ltd. All rights reserved.
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