Journal
JOURNAL OF CHEMICAL RESEARCH
Volume -, Issue 5, Pages 296-300Publisher
SCIENCE REVIEWS 2000 LTD
DOI: 10.3184/030823410X12746350585058
Keywords
heteroaryl-substituted thiazolidinone; configuration; diastereomer; NOE-difference; X-ray crystallography
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Some heteroaryl-substituted thiazolidin-4-one derivatives have been synthesised starting from thiophenecarbox-aldehydes, 2-amino-6-methylpyridine and 2-mercaptoacetic acid. However, the use of 2-mercaptopropanoic acid gave the thiazolidinone derivatives as a mixture of cis-and trans-isomers. The configuration of both the cis-and trans-isomers has been established by NOE-difference experiments. Furthermore, the stereochemistry of one of the trans isomers was established by X-ray crystallography.
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