Journal
NEURON
Volume 87, Issue 4, Pages 684-698Publisher
CELL PRESS
DOI: 10.1016/j.neuron.2015.07.033
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Funding
- NINDS NIH HHS [P01 NS079419, T32 NS007292] Funding Source: Medline
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Autism spectrum disorders (ASDs) and related neurological disorders are associated with mutations in many genes affecting the ratio between neuronal excitation and inhibition. However, understanding the impact of these mutations on network activity is complicated by the plasticity of these networks, making it difficult in many cases to separate initial deficits from homeostatic compensation. Here we explore the contrasting evidence for primary defects in inhibition or excitation in ASDs and attempt to integrate the findings in terms of the brain's ability to maintain functional homeostasis.
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