Journal
NEURON
Volume 88, Issue 1, Pages 220-235Publisher
CELL PRESS
DOI: 10.1016/j.neuron.2015.09.034
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Funding
- European Young Investigator Award
- HFSP [RGP0070/2003]
- Volkswagen Foundation [I/79876]
- European Union [HEALTH-F2-2008-200728, HBP-604102]
- NIH [1U54MH091657]
- DFG [FOR 1847]
- LOEWE (NeFF)
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I propose that synchronization affects communication between neuronal groups. Gamma-band (30-90 Hz) synchronization modulates excitation rapidly enough that it escapes the following inhibition and activates postsynaptic neurons effectively. Synchronization also ensures that a presynaptic activation pattern arrives at postsynaptic neurons in a temporally coordinated manner. At a postsynaptic neuron, multiple presynaptic groups converge, e.g., representing different stimuli. If a stimulus is selected by attention, its neuronal representation shows stronger and higher-frequency gamma-band synchronization. Thereby, the attended stimulus representation selectively entrains postsynaptic neurons. The entrainment creates sequences of short excitation and longer inhibition that are coordinated between pre-and postsynaptic groups to transmit the attended representation and shut out competing inputs. The predominantly bottom-up-directed gamma-band influences are controlled by predominantly top-down-directed alpha-beta-band (8-20 Hz) influences. Attention itself samples stimuli at a 7-8 Hz theta rhythm. Thus, several rhythms and their interplay render neuronal communication effective, precise, and selective.
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