Journal
NEURON
Volume 87, Issue 6, Pages 1143-1161Publisher
CELL PRESS
DOI: 10.1016/j.neuron.2015.09.012
Keywords
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Categories
Funding
- NIH [5R01N2026143]
- Kavli Institute for Neuroscience at Yale
- NARSAD Young Investigator award
- Alfred P. Sloan Fellowship award
- Whitehall grant
- Klingenstein fellowship award
- McKnight Scholar award
- NIH/NEI [R00 EY018407, R01 EY022951]
- Rubicon Grant (Netherlands Organization for Science)
- Jane Coffin Childs Fund fellowship award
- Beckman Young Investigator Award [DP1EY023176, DP1OD008301, P30EY002520, T32EY07001]
- [F32 DC012449]
- [F30MH095440]
- [T32GM007330]
- [T32EB006350]
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The state of the brain and body constantly varies on rapid and slow timescales. These variations contribute to the apparent noisiness of sensory responses at both the neural and the behavioral level. Recent investigations of rapid state changes in awake, behaving animals have provided insight into the mechanisms by which optimal sensory encoding and behavioral performance are achieved. Fluctuations in state, as indexed by pupillometry, impact both the signal (sensory evoked response) and the noise (spontaneous activity) of cortical responses. By taking these fluctuations into account, neural response (co)variability is significantly reduced, revealing the brain to be more reliable and predictable than previously thought.
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