Journal
NEURON
Volume 88, Issue 6, Pages 1253-1267Publisher
CELL PRESS
DOI: 10.1016/j.neuron.2015.11.002
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Funding
- NIH [EY022577, EY019005, MH063912]
- Gatsby Charitable Foundation
- National Science Foundation
- Martinet Foundation
- Howard Hughes Medical Institute
- University of California, San Diego Medical Scientist Training Program [T32 GM007198-40]
- Brain & Behavior Research Foundation
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Cortical layer 5 (L5) pyramidal neurons integrate inputs from many sources and distribute outputs to cortical and subcortical structures. Previous studies demonstrate two L5 pyramid types: cortico-cortical (CC) and cortico-subcortical (CS). We characterize connectivity and function of these cell types in mouse primary visual cortex and reveal a new subtype. Unlike previously described L5 CC and CS neurons, this new subtype does not project to striatum [cortico-cortical, non-striatal (CC-NS)] and has distinct morphology, physiology, and visual responses. Monosynaptic rabies tracing reveals that CC neurons preferentially receive input from higher visual areas, while CS neurons receive more input from structures implicated in top-down modulation of brain states. CS neurons are also more direction-selective and prefer faster stimuli than CC neurons. These differences suggest distinct roles as specialized output channels, with CS neurons integrating information and generating responses more relevant to movement control and CC neurons being more important in visual perception.
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