Journal
NEURON
Volume 88, Issue 2, Pages 298-305Publisher
CELL PRESS
DOI: 10.1016/j.neuron.2015.08.039
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Funding
- Swiss National Science Foundation
- European Research Council
- EPFL
- Hebrew University in Jerusalem
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Goal-directed sensorimotor transformation drives important aspects of mammalian behavior. The striatum is thought to play a key role in reward-based learning and action selection, receiving glutamatergic sensorimotor signals and dopaminergic reward signals. Here, we obtain whole-cell membrane potential recordings from the dorsolateral striatum of mice trained to lick a reward spout after a whisker deflection. Striatal projection neurons showed strong task-related modulation, with more depolarization and action potential firing on hit trials compared to misses. Direct pathway striatonigral neurons, but not indirect pathway striatopallidal neurons, exhibited a prominent early sensory response. Optogenetic stimulation of direct pathway striatonigral neurons, but not indirect pathway striatopallidal neurons, readily substituted for whisker stimulation evoking a licking response. Our data are consistent with direct pathway striatonigral neurons contributing a go'' signal for goal-directed sensorimotor transformation leading to action initiation.
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