Journal
NEURON
Volume 86, Issue 3, Pages 813-826Publisher
CELL PRESS
DOI: 10.1016/j.neuron.2015.03.041
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Funding
- National Center for Responsible Gaming
- Louis V. Gerstner, Jr. Scholar Grant
- Paul Janssen Translational Research Fellowship
- Burroughs Wellcome CAMS Award
- [F32MH100888]
- [T32 MH015174]
- [R01 MH082773]
- [K08 MH087718]
- [R01 MH083862]
- [R37 MH068542]
- Grants-in-Aid for Scientific Research [15H03123, 25117005] Funding Source: KAKEN
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Impulsive and aggressive behaviors are both modulated by serotonergic signaling, specifically through the serotonin 1B receptor (5-HT1BR). 5-HT1BR knockout mice show increased aggression and impulsivity, and 5-HT1BR polymorphisms are associated with aggression and drug addiction in humans. To dissect the mechanisms by which the 5-HT1BR affects these phenotypes, we developed a mouse model to spatially and temporally regulate 5-HT1BR expression. Our results demonstrate that forebrain 5-HT1B heteroreceptors expressed during an early postnatal period contribute to the development of the neural systems underlying adult aggression. However, distinct heteroreceptors acting during adulthood are involved in mediating impulsivity. Correlating with the impulsivity, dopamine in the nucleus accumbens is elevated in the absence of 5-HT1BRs and normalized following adult rescue of the receptor. Overall, these data show that while adolescent expression of 5-HT1BRs influences aggressive behavior, a distinct set of 5-HT1B receptors modulates impulsive behavior during adulthood.
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