Journal
NEURON
Volume 86, Issue 1, Pages 304-318Publisher
CELL PRESS
DOI: 10.1016/j.neuron.2015.03.005
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Funding
- Medical Research Council
- Agence Nationale de la Recherche
- NIH [R01NS060921, F31NS079036]
- NSF [1257923]
- MRC [MR/J008648/1] Funding Source: UKRI
- Direct For Biological Sciences
- Division Of Integrative Organismal Systems [1257923] Funding Source: National Science Foundation
- Medical Research Council [MR/J008648/1] Funding Source: researchfish
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The neural substrates of motor programs are only well understood for small, dedicated circuits. Here we investigate how a motor program is constructed within a large network. We imaged populations of neurons in the Aplysia pedal ganglion during execution of a locomotion motor program. We found that the program was built from a very small number of dynamical building blocks, including both neural ensembles and low-dimensional rotational dynamics. These map onto physically discrete regions of the ganglion, so that the motor program has a corresponding modular organization in both dynamical and physical space. Using this dynamic map, we identify the population potentially implementing the rhythmic pattern generator and find that its activity physically traces a looped trajectory, recapitulating its low-dimensional rotational dynamics. Our results suggest that, even in simple invertebrates, neural motor programs are implemented by large, distributed networks containing multiple dynamical systems.
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