Journal
ACTA BIOMATERIALIA
Volume 13, Issue -, Pages 354-363Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.actbio.2014.11.010
Keywords
Porous TiO2; Nanoparticle; Surface functionalization; Controllable release; Targeting
Funding
- National Basic Research Program of China (973 Program) [2009CB930300]
- National Natural Science Foundation of China [81273449]
- Major National Platform for Innovative Pharmaceuticals of China [2009ZX09301-012]
- Laboratory of Drug Preparation Design & Evaluation of Liaoning Provincial Education Department
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Novel multifunctional porous titanium dioxide (TiO2) nanoparticles modified with polyethylenimine (PEI) were developed to explore the feasibility of exploiting the photocatalytic property of titanium dioxide to achieve ultraviolet (UV) light triggered drug release. Additionally, in order to further realize targeting delivery, folic acid, which chemically conjugated to the surface of the functionalized multifunctional porous TiO2 nanoparticles through amide linkage with free amine groups of PEI, was used as a cancer-targeting agent to effectively promote cancer-cell-specific uptake through receptor-mediated endocytosis. And a typical poorly water-soluble anti-cancer drug, paclitaxel, was encapsulated in multifunctional porous TiO2 nanoparticles. The PEI on the surface of multifunctional porous TiO2 nanoparticles could effectively block the channel to prevent premature drug release, thus providing enough circulation time to target cancer cells. Following UV light radiation, PEI molecules on the surface were cut off by the free radicals (OH center dot and O-2) that TiO2 produced, and then the drug loaded in the carrier was released rapidly into the cytoplasm. Importantly, the amount of drug released from multifunctional porous TiO2 nanoparticles can be regulated by the UV-light radiation time to further control the anti-cancer effect. This multifunctional porous TiO2 nanoparticle exhibits a combination of stimuli-triggered drug release and cancer cell targeting. The authors believe that the present study will provide important information for the use of porous TiO2 nanomaterials in light-controlled drug release and targeted therapy. (C) 2014 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
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