Journal
JOURNAL OF CHEMICAL PHYSICS
Volume 138, Issue 8, Pages -Publisher
AMER INST PHYSICS
DOI: 10.1063/1.4792252
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Funding
- EPSRC
- EPSRC [EP/I001352/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/I001352/1] Funding Source: researchfish
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We use a recently developed coarse-grained model to simulate the overstretching of duplex DNA. Overstretching at 23 degrees C occurs at 74 pN in the model, about 6-7 pN higher than the experimental value at equivalent salt conditions. Furthermore, the model reproduces the temperature dependence of the overstretching force well. The mechanism of overstretching is always force-induced melting by unpeeling from the free ends. That we never see S-DNA (overstretched duplex DNA), even though there is clear experimental evidence for this mode of overstretching under certain conditions, suggests that S-DNA is not simply an unstacked but hydrogen-bonded duplex, but instead probably has a more exotic structure. (C) 2013 American Institute of Physics. [http://dx.doi.org/10.1063/1.4792252]
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