Journal
JOURNAL OF CHEMICAL PHYSICS
Volume 136, Issue 3, Pages -Publisher
AIP Publishing
DOI: 10.1063/1.3677191
Keywords
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Funding
- European Space Agency [ESA AO-2004-070]
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A general theory of nucleation for colloids and macromolecules in solution is formulated within the context of fluctuating hydrodynamics. A formalism for the determination of nucleation pathways is developed and stochastic differential equations for the evolution of order parameters are given. The conditions under which the elements of classical nucleation theory are recovered are determined. The theory provides a justification and extension of more heuristic equilibrium approaches based solely on the free energy. It is illustrated by application to the low-concentration/high-concentration transition in globular proteins, where a novel two-step mechanism is identified, where the first step involves the formation of long-wavelength density fluctuations, and the second step is the actual nucleation event occurring within the fluctuation. (C) 2012 American Institute of Physics. [doi:10.1063/1.3677191]
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