Journal
NEURON
Volume 85, Issue 2, Pages 418-428Publisher
CELL PRESS
DOI: 10.1016/j.neuron.2014.12.033
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Funding
- Wellcome trust [097267/Z/11/Z, WT088312AIA, WT104765MA, 098362/Z/12/Z, 091593/Z/10/Z]
- Biomedical Research Council
- Joint Initiative on Computational Psychiatry and Ageing Research
- James S. McDonnell Foundation
- Wellcome Trust [097267/Z/11/Z] Funding Source: Wellcome Trust
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Learning induces plasticity in neuronal networks. As neuronal populations contribute to multiple representations, we reasoned plasticity in one representation might influence others. We used human fMRI repetition suppression to show that plasticity induced by learning another individual's values impacts upon a value representation for oneself in medial prefrontal cortex (mPFC), a plasticity also evident behaviorally in a preference shift. We show this plasticity is driven by a striatal prediction error,'' signaling the discrepancy between the other's choice and a subject's own preferences. Thus, our data highlight that mPFC encodes agent-independent representations of subjective value, such that prediction errors simultaneously update multiple agents' value representations. As the resulting change in representational similarity predicts interindividual differences in the malleability of subjective preferences, our findings shed mechanistic light on complex human processes such as the powerful influence of social interaction on beliefs and preferences.
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