Journal
NEURON
Volume 85, Issue 4, Pages 710-717Publisher
CELL PRESS
DOI: 10.1016/j.neuron.2015.01.001
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Funding
- LMU Research Fellowship program, a UoC Advanced Postdoctorate Grant
- Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD)
- Deutsche Forschungsgemeinschaft [SFB870, SFB1080]
- Bundesministerium fur Bildung und Forschung
- Belgian Science Policy Office (Wibrain)
- Howard Hughes Medical Institute (SIRS) [55007652]
- Humboldt Foundation (Friedrich Wilhelm Bessel Reseach Award)
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Neurogenesis in the dentate gyrus (DG) of the adult hippocampus is a process regulated by experience. To understand whether experience also modifies the connectivity of new neurons, we systematically investigated changes in their innervation following environmental enrichment (EE). We found that EE exposure between 2-6 weeks following neuron birth, rather than merely increasing the number of new neurons, profoundly affected their pattern of monosynaptic inputs. Both local innervation by interneurons and to even greater degree long-distance innervation by cortical neurons were markedly enhanced. Furthermore, following EE, new neurons received inputs from CA3 and CA1 inhibitory neurons that were rarely observed under control conditions. While EE-induced changes in inhibitory innervation were largely transient, cortical innervation remained increased after returning animals to control conditions. Our findings demonstrate an unprecedented experience-dependent reorganization of connections impinging onto adult-born neurons, which is likely to have important impact on their contribution to hippocampal information processing.
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