Journal
ACTA BIOMATERIALIA
Volume 26, Issue -, Pages 355-365Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.actbio.2015.07.046
Keywords
H2O2; Albumin; Corrosion; Titanium; Ti6Al4V; Implant
Funding
- University Of Birmingham
- China Scholarship Council
- National Institute for Health Research Clinician Scientist Award [NIHR/CS/010/001]
- National Institute for Health Research [NIHR/CS/010/001] Funding Source: researchfish
- National Institutes of Health Research (NIHR) [NIHR/CS/010/001] Funding Source: National Institutes of Health Research (NIHR)
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The synergistic effect of albumin and H2O2 on corrosion of titanium alloy Ti6Al4V in physiological saline was investigated with long-term immersion tests and electrochemical methods. It was found that in the presence of both albumin and H2O2, the rate of metal release in immersion tests was far higher than in the presence of either species alone. Electrochemical polarisation curves and potentiostatic tests showed that H2O2 increased both the rates of the anodic and cathodic reactions, whilst albumin significantly decreased the rate of the cathodic reaction and slightly decreased the rate of the anodic reaction. The synergistic effect of albumin and H2O2 during immersion tests was attributed to the effect of adsorption of albumin in lowering the rate of the cathodic reaction and thus lowering the open circuit potential into the active region of titanium where complexation by H2O2 increased the corrosion rate. The corrosion attack was found to be greater in the beta-phase of the alloy. The findings suggest that current standard tests in physiological or phosphate-buffered saline may underestimate the rate of corrosion in the pen-implant environment, in which albumin is the predominant protein, and reactive oxygen species such as H2O2 can occur as a result of inflammatory reactions in response to surgery, infection, or implant corrosion products. Statement of significance Corrosion of many biomedical implant materials occurs in the body leading to adverse biological responses. Several components of the environment into which a metal implant is placed including proteins and products of cellular physiology, been shown to modify corrosion resistance. Previously all studies on such components including the common protein albumin and the inflammatory product H2O2 have considered the effects of these species in isolation. For the first time we report a synergistic interaction between albumin and H2O2 significantly accelerating corrosion of Ti6Al4V at physiological pH and temperature. This is attributed to an increased rate of the anodic reaction caused by H2O2 complexation of Ti, suppression of cathodic reaction by albumin adsorption shifting OCP to the active region of Ti6Al4V. (C) 2015 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
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