Journal
JOURNAL OF CHEMICAL PHYSICS
Volume 131, Issue 9, Pages -Publisher
AMER INST PHYSICS
DOI: 10.1063/1.3212597
Keywords
biodiffusion; fluorescence; molecular biophysics; proteins
Funding
- Swiss National Science Foundation
- Human Frontier Science Program
- National Institutes of Health, NIDDK
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Fluorescence intensity correlation functions contain information about photophysical and conformational dynamics. We propose and implement a simple procedure to analyze such functions measured in the presence of resonance energy transfer. When there is a separation of time scales and the conformational dynamics is modeled as diffusion in the potential of mean force along the interdye distance, we obtain an analytic expression for the conformational correlation time. This can be used to find the diffusion coefficient describing conformational fluctuations given the photon count rate and equilibrium distribution.
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