4.7 Article

Cell-to-cell communication: Time and length scales of ligand internalization in cultures of suspended cells

Journal

JOURNAL OF CHEMICAL PHYSICS
Volume 128, Issue 22, Pages -

Publisher

AMER INST PHYSICS
DOI: 10.1063/1.2936845

Keywords

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Funding

  1. Intramural NIH HHS [Z99 CT999999] Funding Source: Medline
  2. NIAID NIH HHS [N01AI50021] Funding Source: Medline
  3. PHS HHS [HHSN266200500021C] Funding Source: Medline

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A problem of cell-to-cell communication by diffusible ligands is analyzed for the case when cells are distributed in three dimensions and diffusible ligands are secreted by cells and reversibly bind to cell surface receptors. Following its binding to a receptor, the ligand can either dissociate and be released back in the medium or be absorbed by the cell in a process that is called internalization. Using an effective medium approximation, we derive analytical expressions that characterize the time and length scales associated with the ligand trajectories leading to internalization. We discuss the applicability of our approximation and illustrate the application of our results to a specific cellular system. (C) 2008 American Institute of Physics.

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