Journal
JOURNAL OF CHEMICAL NEUROANATOMY
Volume 38, Issue 1, Pages 1-8Publisher
ELSEVIER
DOI: 10.1016/j.jchemneu.2009.05.007
Keywords
Pyridoxal; Pyridoxine; Vitamin C; Nicotinamide; Immunocytochemistry; Macaca fascicularis
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Funding
- GEMAC S.A. Laboratories
- IDRPHT (Talence, France)
- INCYL (Salamanca, Spain)
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Using highly specific antisera directed against vitamins, the distribution of pyridoxal-, pyridoxine-, vitamin C- and nicotinamide-immunoreactive structures in the monkey (Macaca fascicularis) brain was studied. Neither immunoreactive structures containing pyridoxine or nicotinamide, nor immunoreactive fibers containing vitamin C were found in the monkey brain. However, this work reports the first visualization and the morphological characteristics of pyridoxal- and vitamin C-immunoreactive cell bodies in the mammalian central nervous system using an indirect immunoperoxidase technique. A high density of pyridoxal-immunoreactive cell bodies was found in the paraventricular hypothalamic nucleus and in the supraoptic nucleus and a low density of the same was observed in the periventricular hypothalamic region, whereas a moderate density of vitamin C-immunoreactive cell bodies was observed in the somatosensorial cortex (precentral gyrus). Immunoreactive fibers containing pyridoxal were only visualized in the anterior commissure. The restricted distribution of pyridoxal and vitamin C in the monkey brain suggests that both vitamins could be involved in very specific physiological mechanisms. (C) 2009 Elsevier B.V. All rights reserved.
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