Journal
JOURNAL OF CHEMICAL EDUCATION
Volume 91, Issue 1, Pages 52-55Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ed300677t
Keywords
High School/Introductory Chemistry; Biochemistry; Computer-Based Learning; Hands-On Learning/Manipulatives; Inquiry-Based/Discovery Learning; Amino Acids; X-ray Crystallography; Proteins/Peptides; Enzymes; Molecular Modeling
Funding
- NSF CAREER award [0845445]
- Georgia Intern Fellowship for Teachers program
- Center for Education Integrating Science, Mathematics, and Computing at Georgia Tech
- Div Of Molecular and Cellular Bioscience
- Direct For Biological Sciences [0845445] Funding Source: National Science Foundation
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Here we present a multidisciplinary educational unit intended for general, advanced placement, or international baccalaureate-level high school science, focused on the three-dimensional structure of proteins and their connection to function and disease. The lessons are designed within the framework of the Next Generation Science Standards to make learning more relevant to daily life, and to help high school students engage in and understand advanced topics beyond the typical high school chemistry or biology curriculum. The unit involves lectures, videos, a hands-on activity, a research paper, a laboratory experiment, and a culminating project. Students are introduced to protein crystallography, the protein data bank, and the computer program PyMOL (free download for educational use) to visualize protein structure in three dimensions. Clear improvements in student comprehension of protein structure and function have been documented after implementation of the unit.
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