Journal
NEUROLOGY
Volume 85, Issue 1, Pages 56-62Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1212/WNL.0000000000001712
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Funding
- Alzheimer's Association [NIRG-12-243012]
- NIH [K23AG044431, F32AG044054, K23 AG033634, 8KL2TR000168-05, R01EB014894, R21 AG038994, R01 AG026484]
- Halloran Consulting Group
- Grifols
- Bayer
- Biogen Idec
- Bristol-Myers Squibb
- GE Healthcare
- Isis Pharmaceuticals Inc.
- Janssen Alzheimer's Immunotherapy
- Piramal
- Siemens Medical Solutions
- Genzyme
- GEHC
- Lundbeck
- Pfizer
- Eisai
- Janssen Alzheimer Immunotherapy
- Merck
- Roche
- Eli Lilly
- Fidelity Investigator-Initiated grant
- Alzheimer Association [SGCOG-13-282201]
- The NIH [R01 AG034556, P50 AG00513421, U19 AG10483, P01 AG036694, R13 AG042201174210, R01 AG027435, R01 AG037497, U01 AG032438, U01 AG024904, K24 AG035007, P50 AG005134, U19 AG010483, R01 MH090291]
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Objective: To determine whether neuroimaging biomarkers of amyloid-beta (A beta) and neurodegeneration (ND) are associated with greater self-reported subjective cognitive concerns (SCC) in clinically normal older individuals. Methods: A total of 257 participants underwent Pittsburgh compound B PET, PET with fluorodeoxyglucose F-18, and structural MRI, as well as a battery of neuropsychological measures including several questionnaires regarding SCC. Individuals were classified into 4 biomarker groups: biomarker negative (A beta-/ND-), amyloidosis alone (A beta+/ND-), amyloidosis plus ND (A beta+/ND+), and ND alone (A beta-/ND+). Results: Both A beta and ND were independently associated with greater SCC controlling for objective memory performance. By contrast, neither A beta nor ND was associated with objective memory performance controlling for SCC. Further examination revealed greater SCC in individuals with A beta or ND positivity compared to biomarker-negative individuals. In addition, greater SCC predicted A beta positivity when controlling for ND status. Conclusions: When individuals were grouped by biomarker status, those who were positive on A beta or ND had the highest report of SCC compared to biomarker-negative individuals. Findings were consistent when SCC was used to predict A beta positivity. Taken together, results suggest that both A beta and ND are associated with SCC, independent of objective memory performance. Enrichment of individuals with SCC may increase likelihood of A beta and ND markers in potential participants for secondary prevention trials.
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