Journal
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
Volume 34, Issue 7, Pages 1091-1095Publisher
SAGE PUBLICATIONS INC
DOI: 10.1038/jcbfm.2014.70
Keywords
centrality; functional connectivity; microangiopathy; small vessel disease
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Funding
- LIFE-Leipzig Research Center for Civilization Diseases at the University of Leipzig - European Union, European Regional Development Fund
- Free State of Saxony within the framework of the excellence initiative
- German Consortium for Frontotemporal Lobar Degeneration - German Federal Ministry of Education and Research
- MaxNet Aging
- Parkinson's Disease Foundation [PDF-IRG-1307]
- IFB-Integrated Research and Treatment Center Adiposity Diseases at the University of Leipzig - German Federal Ministry of Education and Research
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Cerebral small vessel disease, mainly characterized by white matter lesions and lacunes, has a high clinical impact as it leads to vascular dementia. Recent studies have shown that this disease impairs frontoparietal networks. Here, we apply resting-state magnetic resonance imaging and data-driven whole-brain imaging analysis methods (eigenvector centrality) to investigate changes of the functional connectome in early small vessel disease. We show reduced connectivity in frontoparietal networks, whereas connectivity increases in the cerebellum. These functional changes are closely related to white matter lesions and typical neuropsychological deficits associated with small vessel disease.
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