Journal
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
Volume 32, Issue 1, Pages 17-22Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/jcbfm.2011.146
Keywords
ischemia; neuronal culture; oxygen and glucose deprivation (OGD); posttranslational modification; SENP-1; SUMO
Categories
Funding
- Wellcome Trust
- BBSRC
- MRC
- ERC
- MRC [G0601810] Funding Source: UKRI
- Medical Research Council [G0601810] Funding Source: researchfish
Ask authors/readers for more resources
Here, we show that oxygen and glucose deprivation (OGD) causes increased small ubiquitin-like modifier (SUMO)-1 and SUMO-2/3 conjugation to substrate proteins in cultured hippocampal neurones. Surprisingly, the SUMO protease SENP-1, which removes SUMO from conjugated proteins, was also increased by OGD, suggesting that the neuronal response to OGD involves a complex interplay between SUMOylation and deSUMOylation. Importantly, decreasing global SUMOylation in cultured hippocampal neurones by overexpression of the catalytic domain of SENP-1 increased neuronal vulnerability to OGD-induced cell death. Taken together, these results suggest a neuroprotective role for neuronal SUMOylation after OGD. Journal of Cerebral Blood Flow & Metabolism (2012) 32, 17-22; doi:10.1038/jcbfm.2011.146; published online 12 October 2011
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available