Journal
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
Volume 30, Issue 11, Pages 1821-1824Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/jcbfm.2010.160
Keywords
blood-brain partition coefficient; cerebral blood flow; cerebral blood flow measurement; mice; MRI
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Funding
- European Union (European Stroke Network) [FP7/2008-2013, 201024, 202213]
- German Ministry for Health and Education (BMBF)
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Cerebral blood flow (CBF) quantification is a valuable tool in stroke research. Mice are of special interest because of the potential of genetic engineering. Magnetic resonance imaging (MRI) provides repetitive, noninvasive CBF quantification. Many MRI techniques require the knowledge of the brain-blood partition coefficient (BBPC) for water. Adopting an MRI protocol described by Roberts et al (1996) in humans, we determined the BBPC for water in 129S6/SvEv mice from proton density measurements of brain and blood, calibrated with deuterium oxide/water phantoms. The average BBPC for water was 0.89 +/- 0.03 mL/g, with little regional variation within the mouse brain. Journal of Cerebral Blood Flow & Metabolism (2010) 30, 1821-1824; doi:10.1038/jcbfm.2010.160; published online 15 September 2010
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