Journal
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
Volume 30, Issue 11, Pages 1860-1873Publisher
SAGE PUBLICATIONS INC
DOI: 10.1038/jcbfm.2010.105
Keywords
blood effective viscosity; cerebral blood flow; hemodynamics; microcirculation; pressure distribution; vessel network topology
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Funding
- ASUPS AOS of Paul Sabatier University, Toulouse, France
- ANR [ANR-06-BLAN-0238-01]
- [GDR 2760]
- Agence Nationale de la Recherche (ANR) [ANR-06-BLAN-0238] Funding Source: Agence Nationale de la Recherche (ANR)
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We report new results on blood flow modeling over large volumes of cortical gray matter of primate brain. We propose a network method for computing the blood flow, which handles realistic boundary conditions, complex vessel shapes, and complex nonlinear blood rheology. From a detailed comparison of the available models for the blood flow rheology and the phase separation effect, we are able to derive important new results on the impact of network structure on blood pressure, hematocrit, and flow distributions. Our findings show that the network geometry (vessel shapes and diameters), the boundary conditions associated with the arterial inputs and venous outputs, and the effective viscosity of the blood are essential components in the flow distribution. In contrast, we show that the phase separation effect has a minor function in the global microvascular hemodynamic behavior. The behavior of the pressure, hematocrit, and blood flow distributions within the network are described through the depth of the primate cerebral cortex and are discussed. Journal of Cerebral Blood Flow & Metabolism (2010) 30, 1860-1873; doi:10.1038/jcbfm.2010.105; published online 21 July 2010
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